I recently discovered 2 GM's, 1 Mic, a truly outstanding general RPG podcast. I really can't say enough good things about this one. The hosts are personable, knowledgeable, and discuss their chosen topics without discussing them to death. They focus on a wide variety of games and topics, including the "Favorite Game of the Week," a notion that appeals greatly to my Gamer ADD. Best of all, they seem to understand economy. Each podcast runs right around an hour, and I have yet to see the sort of bloat that often infects podcasters (Order 66, I'm looking at you).
It's a fun show, and well worth checking out.